It was originally approved for adults and children over 1 year of age with heart failure with reduced ejection fraction (HFrEF).
Who is Entresto recommended for?Įntresto is FDA-approved for chronic (long-term) heart failure in adults. Sacubitril also helps the body get rid of extra fluid, and helps with fluid retention– which is a common problem in people with long-term heart failure. Blocking neprilysin raises levels of several substances in the body that have beneficial effects on the heart, blood vessels, and kidneys, which can help with blood flow in people with heart failure. Sacubitril is the part of Entresto that blocks the protein neprilysin. Angiotensin II receptor blockers are already standard treatment for heart failure with reduced ejection fraction (HFrEF). Expanding blood vessels lowers blood pressure, and makes it easier for the heart to pump blood to the rest of the body. The valsartan portion of Entresto works by blocking a hormone that causes blood vessels to narrow. It can also help improve the heart’s pumping function. An ARNI can take stress off of the heart and help with fluid retention. The medication class name for Entresto is angiotensin receptor neprilysin inhibitor, or ARNI for short. What is Entresto and how does it work?Įntresto is a mixture of two medications: valsartan (Diovan) an angiotensin II receptor blocker ( ARB), and sacubitril which is a neprilysin inhibitor. Here’s what you need to know about Entresto, including how it works, the usual doses, and what side effects to keep an eye out for when taking it. Entresto contains a mixture of older and newer ingredients. It has been shown to reduce hospitalizations and save lives in people with long-term (chronic) heart failure. Entresto (sacubitril/valsartan) is the first and only medication in its class, which is approved for both heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF).
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